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Research trials

Current studies include

Autism

The Autism Cohort Study (ASC-UK) looks into the Autism Spectrum Disorder life course and ageing. The study asks adults on the autism spectrum to complete information about their life experiences on topics such as their autism diagnosis, information about their physical and mental health and life-course information (for example, social support, employment, lifestyle choices). Participants are given a ‘contact booklet’ from their clinician or research assistant which includes an information sheet and a contact form to be completed and returned if they are interested in taking part in the study. Once the Adults completed contact booklet has been received the research study team will send out a more detailed participant information sheet (in an easy to read format), a study consent form, as well as some questionnaires to be completed.

Bipolar disorder

The Ebselen Study aims to demonstrate a therapeutic effect of Ebselen as an ‘add-on’ treatment in patients currently experiencing hypo/mania. Participation involves weekly appointments with the study team over a 4 week period. Participants will be randomised to either Ebselen 600mg twice daily or a placebo. During the 4 week’s, participants will complete self-rated questionnaires and wear an active watch.  

Studies for Carers

COP-e Support aims to establish whether an online platform of digital resources is helpful for carers to someone with psychosis. Participation involves using the internet resources and completing online questionnaires.

Children and Young People

Assessing Mistrust in Young People aims to assess levels of mistrust in young people attending child and mental health services. Participation involves a 5-minute questionnaire.

Parent-Adolescent Interactions in the Treatment of Adolescents with Depression (PAI) is an interview study aiming to understand how adolescents respond to treatment and how to directly target depression more effectively. Participation involves an interview with a researcher.

Psychological Treatments for Anxiety in Adolescents is a survey for clinicians, which aims to understand current psychological treatments for adolescents (aged 11-18) with anxiety disorders in CAMHS services across England. Participation includes completing a 15-minute online survey.

Studies for Clinicians

Mental health practitioner survey into engagement with parenting aims to develop an understanding of clinicians’ experiences of working with service users who are also parents in Adult Mental Health, as well as experiences of working with parents of service users in CAMHS.

Depression

LQD aims to compare the clinical and cost effectiveness of lithium versus quetiapine when used as add-on therapies to antidepressant medication for patients with Treatment Resistant Depression (TRD). Participation involves pre-screening questions usually delivered over the phone. Following this a full screening and baseline assessment will be completed (this involves completing study questionnaires and having blood samples and physical observations taken). Participants are then randomised to either lithium or quetiapine. A research assistant will then meet with the participant at 8, 26 and 52 weeks to complete further questionnaires and blood tests. Participants also complete weekly True Colours self-rated questionnaires.

Eating Disorders

TRIANGLE aims to establish whether an online platform of digital resources is helpful for individuals with anorexia nervosa, and their family member. Participation involves using the internet resources and completing online questionnaires.

Inpatient Wards

Improving Access to Psychological Therapy on Acute Mental Health Wards aims to look at improving access to psychological therapies for people with severe mental health problems on acute mental health wards and involves a 1-hour interview.

Oxford Cognitive Approaches to Psychosis studies

We currently recruit to seven Oxford Cognitive Approaches to Psychosis (OCAP) studies such as Feeling Safe, Virtual Reality, and SlowMo. These studies are generally targeted at patients with psychosis and persecutory delusions and aim to investigate different courses of treatment (such as virtual reality, digital therapy, and psychological therapy). 

Perinatal Studies

CAPRI-Voc invites mothers who have experienced serious mental illness with infants aged between 9-18 months to explore different brain patterns of babies whose mums have experienced mental illness. The aim is to examine how the brain of infants processes voices and to understand how different factors may affect a child’s responses to sounds and voices.

Psychosis and schizophrenia

Alkermes intends to investigate if olanzapine and samidorphan (ALK 3831) can allow patients to have the benefits of olanzapine without the associated weight gain and metabolic risks.

AppRoVE aims to develop questionnaires to measure whether a therapy is helping people develop assertive responding to voices. Participation involves people who hear voices completing some questionnaires with researchers.

EULAST aims to investigate outcomes for patients on oral versus depot medication (Aripiprazole versus Paliperidone). The complete study consists of 21 visits over a period of 18 months for assessments and monitoring. Treatment as usual continues for the duration of the study (clinical team remains involved).

The Otsuka Digital Medicine Study aims to explore the performance and acceptability of a digital medicine system with healthcare professionals and adult subjects with schizophrenia, schizoaffective disorder, or first episode psychosis. Participation involves using the digital medicine system for 8 weeks, and completing three assessments at baseline, 4 weeks, and 8 weeks.

PPIP2 is a pilot study that aims to test enough patients with psychosis to be able to define the prevalence of schizophrenia that is caused by an antibody mediated disorder. Participation involves a blood sample and permission to store the sample for future testing. Participants receive £10 reimbursement for their time.

RADAR is a randomised trial which aims to assess the benefits and risks of a flexible, supported strategy for antipsychotic dose reduction and discontinuation where possible, in people with schizophrenia and non-affective psychosis.

The Sleep & Psychotic Features Study investigates the relationship between sleep and mood in people who have been referred to NHS mental health services, to understand if sleep problems are present in these people.

7-Tesla aims to use an advanced brain imaging system (magnetic resonance spectroscopy) to examine changes in brain chemicals in people with psychosis. This study will focus on a natural chemical messenger called glutamate which is thought to be involved in the development of psychotic symptoms. Participation involves a blood sample, an MRI scan at 7 TESLA (1 hour & 30-minute symptom questionnaire), and cognitive tests (1 hour). Participants receive £75 reimbursement and reasonable travel expenses.

Smoking Cessation

TARS is a study for people who want to reduce, but not quit, smoking. As NHS support is aimed at quitting smoking, this study aims to find out if support from a health trainer and physical exercise can help to reduce smoking as compared to no support. Participation will be 9-15 months long, and may involve wearing an activity watch and weekly meetings with a health trainer. You will receive £40 shopping vouchers for completing the study.

 

To find out more about any of these studies, please email: mentalhealthresearch@oxfordhealth.nhs.uk

Last updated: 20 November, 2018

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