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Research trials

Current studies include

Bipolar disorder

DPIM aims to explore genetic and other causes of mental illness. Participation involves donation of DNA sample (blood or saliva) and completion of questionnaires.

Ebselen is a randomised control trial investigating whether Ebselen can reduce symptoms of hypomania in patients experiencing acute relapse. Participation in the study lasts for four weeks and includes self-rated questionnaires as well as wearing an activity watch. 

Depression

LQD aims to compare Lithium versus Quetiapine as an add-on therapy for treatment resistant depression. Participants will be randomly allocated to one of the medications and will be monitored at eight, 26, and 52 weeks with blood tests, blood pressure, True Colours mood monitoring, and questionnaires.

Rumination explores the mediating relationship of rumination using qualitative and quantitative methods. Participation involves a short interview over phone or Skype and self-report questionnaires.

TACK aims to improve quality of life and clinical outcomes for people with chronic depression. It is a novel technology-assisted and resource-oriented intervention and participation involves three meetings between clinicians and patients for use of app, followed by a face-to-face interview on completion of trial.

BioDep2 is a clinical biomarker study of immunological phenotypes. 

Psychosis and schizophrenia

PPIP2 aims to define the prevalence of psychosis that is caused by an antibody mediated disorder. Participants complete a short questionnaire and provide a blood sample which is then tested and results are shared with them and the clinical team.

EULAST aims to investigate outcomes for patients on oral versus depot medication (Aripiprazole versus Paliperidone). The complete study consists of 21 visits over a period of 18 months for assessments and monitoring. Treatment as usual continues for the duration of the study (clinical team remains involved).

RADAR is a randomised trial which aims to assess the benefits and risks of a flexible, supported strategy for antipsychotic dose reduction and discontinuation where possible, in people with schizophrenia and non-affective psychosis. 

Autism

ASC-UK focuses on the lives of adults on the autistic spectrum and understanding their experiences as they age. Study participation involves completion of questionnaires. 

Eating Disorders

Triangle is an RCT of online support for females and their carers admitted to EDS. 

Oxford Cognitive Approaches to Psychosis studies

We currently recruit to seven Oxford Cognitive Approaches to Psychosis (OCAP) studies such as Feeling Safe, Virtual Reality, and SlowMo. These studies are generally targeted at patients with psychosis and persecutory delusions and aim to investigate different courses of treatment (such as virtual reality, digital therapy, and psychological therapy). 

Children and Young People

Assessing Mistrust in Young People is a questionnaire study aiming to assess the clinically relevant problems of mistrust in age group 11-17.

Parent Adolescent Interactions is a non-interventional study investigating the impact parent – adolescent interactions has on treatment response to therapy. 

 

To find out more about any of these studies, please email: mentalhealthresearch@oxfordhealth.nhs.uk

Last updated: 28 February, 2018

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