Paediatric traumatic brain injury as a risk factor for psychosis and psychotic symptoms: a systematic review and meta-analysis
Abstract
Psychosis is one of the most disabling psychiatric disorders.
Paediatric traumatic brain injury (pTBI) has been cited as a developmental risk factor for psychosis, however this association has never been assessed meta-analytically.
A systematic review and meta-analysis of the association between pTBI and subsequent psychotic disorders/symptoms was performed.
The study was pre-registered (CRD42022360772) adopting a random-effects model to estimate meta-analytic odds ratio (OR) and 95% confidence interval (CI) using the Paule-Mandel estimator.
Subgroup (study location, study design, psychotic disorder vs subthreshold symptoms, assessment type, and adult vs adolescent onset) and meta-regression (quality of evidence) analyses were also performed.
The robustness of findings was assessed through sensitivity analyses.
The meta-analysis is available online as a computational notebook with an open dataset.
We identified 10 relevant studies and eight were included in the meta-analysis.
Based on a pooled sample size of 479,686, the pooled OR for the association between pTBI and psychosis outcomes was 1.80 (95% CI [1.11, 2.95]).
There were no subgroup effects and no outliers.
Both psychotic disorder and subthreshold symptoms were associated with pTBI.
The overall association remained robust after removal of low-quality studies, however the OR reduced to 1.43 (95% CI [1.04, 1.98]).
A leave-one-out sensitivity analysis showed the association was robust to removal of all but one study which changed the estimate to marginally non-significant.
We report cautious meta-analytic evidence for a positive association between pTBI and future psychosis.
New evidence will be key in determining long-term reliability of this finding.
Citations
Paediatric traumatic brain injury as a risk factor for psychosis and psychotic symptoms: a systematic review and meta-analysis King-Chi Yau, Grace Revill, Graham Blackman, Madiha Shaikh, Vaughan Bell medRxiv 2023.02.17.23286118;
Page last reviewed: 12 June, 2025
Metadata
Author(s): Blackman, Graham
Collection: 123456789/31
Subject(s): Brain Injury, Children and Adolescents, Psychosis
Format(s): Preprint
Date issued: 2023-02
ID: 1252